Magnesium

Intended use
Biostep Magnesium reagent is intended for in-vitro quantitative, diagnostic determination of Magnesium in human serum, plasma and urine on both automated and manual systems.
Background
Magnesium is an activator for various physiochemical processes,
including phosphorylation, protein synthesis and DNA metabolism. It is also involved in neuromuscular conduction and excitability of skeletal and cardiac muscle.
Increased serum magnesium concentrations occur in renal failure, acute diabetic acidosis, dehydration or Addison’s disease.
Hypomagnesaemia has a depressing effect on the central nervous system, causing general anesthesia and respiratory failure. It alters the conduction mechanism of the heart, causing cardiac arrest. Hypomagnesaemia may be observed in chronic alcoholism, malabsorption, severe diarrhea, acute pancreatitis, diuretic therapy, prolonged parenteral fluid therapy without magnesium supplementation and the kidney disorders such as glomerulonephritis and tubular reabsorption defects.