G-GT (kinetic)

Intended Use
Biostep Diagnostic’s Ɣ-Glutamyltransferase reagent is intended for the invitro quantitative, diagnostic determination of Ɣ-Glutamyltransferase in human serum on both automated and manual systems.
Background
Ɣ-g-Glutamyltransferase (GGT) is usually most significantly elevated by obstructive disease and has good specificity for the liver. It is not elevated in bone diseases or  pregnancy (as ALP) or in skeletal muscle diseases (as AST). GGT can also help to differentiate between mechanical and viral from drug induced cholestasis. The highest  concentration of GGT is found in the luminal membrane of the proximal tubules of the kidney. Other sources are the pancreas, prostate, and liver. High GGT activity is found in prostate tissue, which may account for the increase GGT activity seen