Total protein

Intended use

Biostep Diagnostics Total protein reagent is intended for the invitro quantitative, diagnostic determination of total protein in human serum or plasma on both automated and manual systems.

Background

Plasma proteins are mainly synthesized in the liver and are involved in the maintenance of normal water distribution between tissues and blood, as well as acid-base balance. Due to some pathological conditions, both total protein level and the ratio of different fractions may change independently of one another. Hyperproteinemia may be detected during dehydration associated with diarrhea or vomiting. The total protein levels also increase in multiple myeloma. Hypoproteinemia may occur as a result of prolonged low protein diet and in some pathological conditions such as nephrotic syndrome, bleeding, sprue, and salt retention.