PTT – CaCl2

Intended Use
Biostep Diagnostics PTT reagent is intended for partial Thromboplastin (APTT) determination using ellagic acid, as an activator.
Background
The arrest of bleeding depends upon primary platelet plug formed along with the formation of a stable fibrin clot. Formation of this clot involves the sequential interaction of a series of plasma proteins in a highly ordered and complex manner and also in the interaction of these complexes with blood platelets and materials released from the tissues. Activated Partial Thromboplastin Time (APTT) is prolonged with a deficiency of coagulation factors of the intrinsic pathway of the human coagulation mechanism such as factor XII, XI, IX, VIII, X, V, II, and Fibrinogen. Determination of APTT helps in estimating abnormality in most of the clotting factors of the intrinsic pathway and is also a sensitive procedure for generating heparin response curves for monitoring heparin therapy.