GPT (kinetic)

Biostep Diagnostic’s ALT reagent is intended for the invitro quantitative, diagnostic determination of ALT in human serum on both automated and manual systems.

Background

The enzyme alanine aminotransferase ALT is widely distributed with high concentrations in the liver and to a lesser extent in kidneys, heart, skeletal muscles, pancreas and lungs. Elevated serum ALT is found in hepatitis, cirrhosis, obstructive jaundice, liver carcinoma and chronic alcohol abuse. ALT is only slightly elevated in patients who have an uncomplicated myocardial infarction. Although both serum aspartate aminotransferase AST and ALT become elevated whenever disease processes affect liver cell integrity, ALT is the more liver specific enzyme. Moreover, elevations of ALT activity persist longer than elevations of AST activity.